A modeling framework is formulated and applied to assess the sensitivity of the hydrological regime of two catchments in a convective rainfall environment with respect to projected climate change. The study uses likely rainfall scenarios with high spatiotemporal resolution that are de- pendent on projected changes in the driving regional meteorological synoptic systems. The framework was applied to a case study in two medium-sized Mediterranean catchments in Israel, affected by convective rainfall, by combining the HiReS-WG rainfall generator and the SAC-SMA hydrolog- ical model. The projected climate change impact on the hy- drological regime was examined for the RCP4.5 and RCP8.5 emission scenarios, comparing the historical (beginning of the 21st century) and future (mid-21st-century) periods from three general circulation model simulations available from CMIP5. Focusing on changes in the occurrence frequency of regional synoptic systems and their impact on rainfall and streamflow patterns, we find that the mean annual rain- fall over the catchments is projected to be reduced by 15% (outer range 2–23%) and 18%(7–25%) for the RCP4.5 sand RCP8.5 emission scenarios, respectively. The mean annual streamflowvolumes are projected to be reduced by 45%(10– 60%) and 47% (16–66 %). The average events’ streamflow volumes for a given event rainfall depth are projected to be lower by a factor of 1.4–2.1. Moreover, the streamflow sea- son in these ephemeral streams is rojected to be shorter by 22%and 26–28%for the RCP4.5 and RCP8.5, respectively. The amplification in reduction of streamflow volumes relative to rainfall amounts is related to the projected reduction in soil moisture, as a result of fewer rainfall events and longer dry spells between rainfall events during the wet sea- son. The dominant factors for the projected reduction in rainfall amount were the reduction in occurrence of wet synop- tic systems and the shortening of the wet synoptic systems durations. Changes in the occurrence frequency of the two dominant types of the regional wet synoptic systems (active Red Sea trough and Mediterranean low) were found to have a minor impact on the total rainfall.